People’s desire for purpose fueled the Great Resignation. The threat of the pandemic, long hours to contemplate what matters, and burnout created a global values–clarification experience. People gained clarity about what they want from their workplaces. Purpose is the driving force that gives our lives meaning. Humans are wired for purpose and recent discoveries in neuroscience offer a fascinating look into what motivates us to become our best selves. The ability to align purpose is what distinguishes the most effective leaders from the rest, and purpose is at the heart of engagement, productivity, and retention. Organizations that know how to harness the power of purpose thrive and excel while their peers falter or fail.